At what age is macular degeneration most commonly observed?

Macular degeneration, particularly age-related macular degeneration (AMD), is a condition that primarily affects older adults. It is characterized by the deterioration of the macula, the part of the retina responsible for central vision. The most significant risk factor for developing AMD is aging, with a substantial increase in prevalence after the age of 65. This age group experiences more degenerative changes in the retina due to various factors, including genetic predisposition, cumulative exposure to environmental stressors, and other age-related physiological changes.

In contrast, the other age ranges listed generally see much lower incidences of macular degeneration. Under 20 years, and even between 30-40 years or 45-60 years, individuals typically do not exhibit significant symptoms or diagnoses of this condition. Therefore, the statement indicating that macular degeneration is most commonly observed in individuals 65 years and older accurately reflects clinical observations and the pathology associated with this disease.